SINGAPORE, June 10 — Next week, 23 healthy volunteers here will be involved in a clinical safety trial for an antibody drug that is hoped to be a viable treatment for patients with Covid-19, a disease that has killed more than 400,000 around the globe so far.
Infectious diseases expert Dr Ooi Eng Eong, who co-founded Tychan, the biotech company behind the treatment, told the media in a video conference on Tuesday (June 10) that if trials prove successful, the drug could in future also be used to render temporary protection against Covid-19 infection, as antibody drugs tend to be effective for about two to three weeks per dose.
As such, the drug ― now known as TY027 ― could perhaps be used to protect frontline healthcare workers against any potential exposure of the novel coronavirus, or travellers when they head to countries with high community transmission of Covid-19, he said.
Using the drug to treat confirmed Covid-19 cases “could reduce a lot of problems we face right now”, Dr Ooi added, such as the limited number of ventilators available at hospitals.
“One obvious thing is that a lot of the (Covid-19 patients) get sick for a very long time, and some of them even get very severe respiratory disease, so much so that you need oxygen ventilators to help them tie through this critical period, without which they would die,” said Dr Ooi, a professor and deputy director of Duke-NUS Medical School’s emerging infectious diseases programme.
“We hope that this treatment that we have will reduce the number of people who go into such a severe (stage), and hopefully the number of people who die from Covid-19 can be kept at a minimum.”
But Dr Ooi noted that the eventual use of the drug and who it will be administered to will depend on the outcome of the Phase 1 clinical safety trial, which will start next week and take about six weeks. The Health Sciences Authority granted approval for the trial on June 8.
This trial, which will be conducted by SingHealth’s investigational medicine unit, will focus on evaluating the safety, tolerability and pharmacokinetics of the antibody. Pharmacokinetics refers to the way the body reacts to the drug.
Thereafter, the drug will still have to undergo more tests before it can be used in real-life clinical settings, and this whole process could take months, Dr Ooi said.
Presently, there is no proven antibody-based treatment for Covid-19. There is also no licensed vaccine to prevent its infection.
This is the first time an in-human trial for a Covid-19 treatment has been approved here.
A team at the Agency for Science, Technology and Research (A*Star) is also in the process of developing a similar antibody, but it is still in its early stages of research.
Tychan said in a statement on Wednesday that it produced this antibody on February 25, in partnership with the Ministry of Defence, the Ministry of Health, the Economic Development Board and other government agencies as part of a whole-of-government collaborative effort.
The company then identified it as being the most promising among several antibodies that demonstrated 100 per cent neutralisation against live SARS-CoV-2 – the virus that causes Covid-19 – in the lab.
Since then, preclinical safety studies and other regulatory requirements. including a three-week drug stability test, have been completed successfully.
Tychan noted that the development of this antibody was fast-tracked, and said it achieved this short turnaround as it had prior experience in the development of therapeutics for Zika and Yellow fever, which took nine months and seven months respectively, from design to first in-human infusion.
Such development typically takes 12 to 18 months, it added.
Tychan’s endeavour to build such a rapid response capability against infectious disease outbreak was first supported by Temasek Foundation Ecosperity and Temasek Life Sciences Lab, the company said. ― TODAY
